Rams vs Niners: Odds, Spread, Preview: NFL Week 4 Predictions

Rams vs 49ers Week 4 matchup preview and current betting lines

The Los Angeles Rams will look to keep their foot on the gas when they visit Santa Clara for a California matchup vs. the San Francisco 49ers. They put that heartbreaking loss in the season opener in the rearview mirror and finally look like contenders again.

The Rams followed that loss to the Buffalo Bills with a big win over the Atlanta Falcons, although they could’ve lost that game in the final play. Then, they got past another divisional rival by topping the Arizona Cardinals on the road in a game that wasn’t as close as one could tell by the final score.

The San Francisco 49ers were forced to change their plans for the season in the blink of an eye. They couldn’t beat the Chicago Bears in hostile weather in the season debut and then lost Trey Lance for the season in the second game of the campaign.

Jimmy Garoppolo weathered the storm in Week Two and helped them get the win over the Seattle Seahawks. Then, his usual struggles were back at full display in a primetime game vs. the Denver Broncos that was the ultimate snoozefest.

Los Angeles Rams vs San Francisco 49ers prediction

Players to watch:

Matthew Stafford: Matthew Stafford’s health continues to be a reason for concern within the Los Angeles Rams organization. He’s completed over 70% of his passes but has only thrown for 761 yards with 4 scores, 5 picks, and a passer rating of 86.2. He must be better if they want to compete at the highest level.

Jimmy Garoppolo: Jimmy Garoppolo is what he is. He’s never going to be that guy who’ll sling the football down the field, nor a mobile pocket-passer who can break tackles and ankles with his feet. He’s held the San Francisco 49ers back for years, so he’ll need to silence his critics and earn a new contract.

Week 4 Predictions: NFL Bet of the week on Rams vs 49ers

Rams +3

The opening Rams vs 49ers spread has the home team favored by a field goal. In al honesty, we believe that they have the wrong team favored, as this version of the San Francisco 49ers is by no means better than the reigning champions Los Angeles Rams.

Yes, Stafford has struggled to find the same success he found last season, and the Niners did a good job of keeping him in check in their last meeting. However, the Rams feature more talent on both sides of the field, and they also know how to get to Jimmy Garoppolo.

Garoppolo is no starte, not at this level. So, even if he went from an afterthought to a starter once again, he’s only making the Niners worse, not better, especially if they don’t have their best running back, Elijah Mitchell, next to him and taking pressure off his shoulders.

The Rams want to make a statement in every divisional game, and this has the perfect setting for that. They already beat the Niners in their last meeting and Stafford should look better with another week to heal. Take the visitors and sprinkle some on the Moneyline as well.

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Under 43.5

The Rams vs 49ers odds have this total sitting at 43.5 points. That makes sense considering these teams take every divisional game with a playoff-like approach, so we can expect a lot of long drives and clock management between two teams that know each other pretty well.

The Los Angeles Rams have one of the best defenses in the league and they proved it again by holding the Arizona Cardinals to just 12 points. They allow just 93 rushing yards per game, which could be a major issue for the Niners’ ground-heavy attack.

The Rams’ offense has yet to click. They average 20.3 points per game, which ranks middle of the pack, and have the worst rushing attack in the league at just 72.3 rushing yards per game. The Niners aren’t much better at just 15.7 points per game (28th in the league).

Kyle Shanahan’s defense has been elite this season. They rank 2nd in total yards per game (246), 1st in passing yards (148.3), and 4th in rushing yards (78.3) while allowing the third-fewest points (12.3). So, feel comfortable riding with the under on this one.

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Frequently Asked Questions about Rams vs 49ers

This game will be played at Levi’s Stadium in San Francisco.

Feel free to visit our NFL odds page for odds on every week’s games.

The Rams won 20-17 on January 30th, 2022.

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Yes! Our player props page features the best props for this week’s slate.