New England Patriots vs. Arizona Cardinals Odds, Spread, Preview: NFL Week 14 Predictions

By Lawrence Smelser

New England Patriots vs. Arizona Cardinals Week 14 matchup preview and current betting lines

Two weeks ago the Patriots were 6-4 and held a spot in the playoff picture. Now, Bill Belichick’s team sits at 6-6 and is on the bubble, behind the No. 7 seed, New York Jets (7-5).

Arizona (4-8) has endured an extremely disappointing season and will have to win out to have a slim chance of earning a postseason berth. The team has lost four of its last five and is coming off a 25-24 heartbreaker against the Chargers in Week 12 (Week 13 was the team’s bye).

The Cardinals took the lead early in the fourth quarter but surrendered a touchdown to Austin Ekeler with just 15 seconds left. Chargers’ head coach Brandon Staley opted to gamble and go for two and was successful.

New England had won six games in a row but lost on Thanksgiving to Minnesota and last week against Buffalo. After taking a 7-3 advantage with 4:46 in the first quarter, the Patriots were outscored 21-3 for the rest of the game.

Oddsmakers at BetMGM Sportsbook give the Patriots a 1.5-point edge over the Cardinals. On the moneyline, New England is -125 and Arizona is +105. Gamblers have put 58% of their bets on the Cardinals to cover and 95% of the money on the Patriots to win straight up.

Kickoff for the Monday Night primetime matchup is set for 8:15 E.T. in Glendale, AZ. ESPN will be broadcasting the matchup.

Players to watch in the Patriots vs. Cardinals contest


Mac Jones: The second-year quarterback hasn’t played as well as the New England faithful would’ve hoped. Jones has thrown for 1,963 yards, seven touchdowns, seven interceptions and boasts a quarterback rating of 35.5 (27th).


Marquise Brown: Arizona’s speedy wide receiver finally returned from injured reserve on Nov. 27. The former Raven has had a bye week of rest and will look to do as much damage as possible against New England. The former Oklahoma Sooner is averaging 75.9 yards per game and has 49 catches for 531 yards as well as three touchdowns this campaign.

Patriots vs. Cardinals prediction and odds

Our NFL bet of the week for the Patriots vs. Cardinals

ESTNN is providing bettors with two free selections for this game.

New England vs. Arizona Alternate Spread: Patriots -1.5 @ -110 (BetMGM)

Arizona has been awful this season. They’ve been bad on the road but even worse at home with a 1-6 record. 

The Cardinals’ front office probably thought their former No. 1 overall pick, Kyler Murray, would improve each season and build off of last year when they went 11-6 and reached the playoffs.

The situation has played out differently and Arizona has struggled nearly every week. In four of its last five losses, the red and white have lost by at least eight or more points.

New England hasn’t been great offensively and ranks 20th in points per game (20.8) and 24th in total defense (318.9). Although, they’ll face a putrid Arizona defense that is second-worst in the NFL in weekly points allowed (26.8) and 21st in total defense (356.2 yards surrendered per contest).

Despite an offense with weapons outside, Arizona has been mediocre in the category. The unit ranks 20th in total offense (334.8 yards per game) and 16th in points per game (22). 

It’ll be a nightmare matchup for Kyler Murray, who isn’t the most accurate quarterback nor the best decision-maker against defensive genius Belichick. The legendary coach’s defense is seventh in both yards allowed (311.8) and is surrendering only 18.8 points each outing.

The Patriots are 6-3 against the spread in their previous nine games and are 7-1 ATS in the last eight meetings with Arizona. The Cardinals are 1-4 ATS in their last five games at home versus the Patriots and are 6-6 ATS this season.

At ESTNN, we believe the Patriots will cover the 1.5-point spread offered by BetMGM. The sportsbook is offering -110 odds for the wager.

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New England vs. Arizona odds: DeAndre Hopkins over 70 rec yards @ -144 (FanDuel)

Hopkins missed the first six games of the season due to the use of a banned substance. Since his return, the former Clemson Tiger has been terrorizing opposing secondaries.

Hopkins is averaging 95.7 yards per game, which is 25.7 more yards than the prop offered at FanDuel. In five of the six contests he’s taken part in, the 30-year-old has recorded at least 86 yards.

DeAndre Hopkins game log

Week 7 vs. NOLA: 10 rec for 104 yards

Week 8 at MIN: 12 rec for 159 yards

Week 9 vs. SEA: 4 rec for 36 yards

Week 10 at LAR: 10 rec for 98 yards

Week 11 vs. SF: 9 rec for 91 yards

Week 12 vs. LAC: 4 rec for 86 yards

Slot receiver Rondale Moore has been ruled out for week 14 so Hopkins will likely see even more volume. In 2022-2023 Hopkins is averaging 10.7 targets per contest.

Our pick is to take the over 70 yards receiving prop on FanDuel at -144 odds. If you’re interested in learning about more prop bets for week 14, read our NFL player props page.

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Frequently asked questions regarding New England vs. Arizona in week 14

The Alabama product was selected 15th overall in the 2021 NFL draft.

If you’re interested in seeing other game lines, read our NFL odds for this week page for more information. 

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