Dallas Cowboys vs. San Francisco 49ers prediction, odds, spread: NFL Playoffs Preview 01/22/2023

By Lawrence Smelser

Dallas Cowboys vs. San Francisco 49ers prediction, matchup preview and current betting lines

The Cowboys will meet with the 49ers for a second-straight postseason on 01/22/2023  at Levi’s Stadium in Santa Clara, California Sunday. Kickoff is slated for 6:30 p.m. ET and the bout can be seen on FOX. 

Dallas (13-5) will be on a revenge mission after being knocked out last year at home to Kyle Shanahan and his team, 23-17 during the Wild Card round. 

San Francisco (13-4) is trying to reach its third NFC Championship in four years under Shanahan. Last season, the organization narrowly lost 20-17 to the Rams. 

Mike McCarthy and the fifth-seeded Cowboys are coming off a 31-14 dismantling of Tom Brady and the Tampa Bay Buccaneers. It was the team’s first road playoff win since they beat San Francisco in 1992.

America’s team is trying to reach its first NFC Championship since the 1996-1997 season. The winner of this weekend’s contest will play the winner between the Giants and Eagles.

The No. 3 seed 49ers enter the week after destroying their division rivals, the Seahawks, 41-23. The California-based team has won 11 straight games while the Cowboys have won five of their last six.

Oddsmakers at Caesars have the odds set in favor of San Francisco winning as four-point favorites on the spread and -190 on the moneyline, compared to Dallas at +190. 

The game total is set at 46.5 points. Currently, 58% of bets have been placed on the 49ers to cover the spread and 78% of the money is on the Cowboys to win outright.

Players to watch in the Cowboys vs. 49ers contest


CeeDee Lamb: The 2023 Pro Bowler became the de-facto WR1 for Dallas when Amari Cooper departed for Cleveland (traded for a fifth-round pick) in the offseason. Lamb answered the call and made 107 catches (T-fifth) for 1,359 yards (sixth) and nine touchdowns (T-sixth) during the regular season.

San Francisco

George Kittle: The Pro Bowl tight end has become Brock Purdy’s safety blanket. The Iowa product has scored seven touchdowns in the six games Purdy has started. For the season, the 29-year-old has recorded 60 receptions for 765 yards, 11 touchdowns (T-third) and is averaging 12.8 yards per catch.

Dallas vs. San Francisco prediction and odds

Our NFL bet of the week for the Cowboys vs. 49ers

ESTNN is providing bettors with two free selections for this game.

Dallas vs. San Francisco: Cowboys (+7) @ -179 (BetMGM)

Two of the most well-balanced teams in the NFL will meet in Sunday’s mouthwatering contest. 

The 49ers have been led by their top-ranked defense that ranks first in points allowed (16.3) yards allowed (300.6) and interceptions (20). San Francisco’s fifth-ranked total offense (365.6 yards per game) has also been excellent scoring an average of 26.5 points per game (sixth).

Dallas defensive coordinator Dan Quinn has built a lethal defense spear-headed by linebacker Micah Parsons. The unit ranks first in turnovers per game, (1.9) tied for third in sacks (54) fifth in points allowed (20.1) and 12th in yards allowed (330.2).

The Cowboys are fourth in points per game (27.5) and 11th in total offense (354.9 yards per game). They did play their first six games with backup Cooper Rush under center.

Since quarterback Dak Prescott returned from a thumb injury in week 7, Dallas owns a 9-3 record, is first in the NFL in points per game (32.3) and is outscoring its opponents by an average of 10.8 points per game.

San Francisco rookie quarterback Brock Purdy has played lights out and exceeded all expectations. The last pick in the 2022 NFL draft is 6-0 as the team’s starter and has thrown for 1,374 yards, 13 touchdowns compared to just four interceptions and owns a quarterback rating of 65.5.

This week will be more challenging for Purdy as he faces Dallas’ eighth-ranked defense against the pass (200.9 YPG). He’ll also have Parsons, the 2021 NFL Defensive Rookie of the Year, with 14.5 sacks this season trying to take him down.

The Cowboys are 11-7 against the spread this season and haven’t lost any game by more than seven points when Dak Prescott played more than the entirety of a game. The 49ers are 12-6 against the spread this year but are 1-5 straight up against Dallas in their last six games when playing them at home.

Our pick at ESTNN is to take Prescott and company to cover an alternate seven-point spread. Caesars Sportsbook is offering -179 odds for the wager.

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Cowboys vs. 49ers odds: Christian McCaffrey anytime TD scorer @ -160 (BetMGM)

The Pro Bowl running back has scored at least one touchdown in his last seven outings. McCaffrey is considered a “Swiss army knife” since he is dangerous both on the ground and through the air.

McCaffrey’s last seven games

NFC Wild Card vs. Seattle: (One receiving TD)

Week 18 vs. Arizona (One receiving TD)

Week 17 at Las Vegas (One rushing TD)

Week 16 vs. Washington (One rushing TD)

Week 15 at Seattle (One rushing TD)

Week 14 vs. Tampa Bay (One rushing and one receiving TD)

Week 13 vs. Miami (One receiving TD)

Since becoming the lead tailback for the 49ers in week eight, the former No. 8 overall pick has tallied 42 total red zone touches (35 rushes and 7 receptions). Despite backup Elijah Mitchell being healthy, the Stanford product will remain the focal point of the offense.

Our pick is to bet on McCaffrey to score a touchdown at -160 odds on BetMGM Sportsbook. If you’re interested in learning about more prop bets for round two of the playoffs, read our NFL player props page.

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Frequently asked questions regarding Dallas vs. San Francisco

The last time Jerry Jones’ team hoisted the Lombardi Trophy was in 1996. The organization defeated the Pittsburgh Steelers 27-17.

If you’re interested in seeing other game lines, read our NFL odds for this week page for more information. 

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