Los Angeles Chargers vs. Arizona Cardinals Odds, Spread, Preview: NFL Week 12 Predictions

By Lawrence Smelser

Los Angeles Chargers vs. Arizona Cardinals Week 12 matchup preview and current betting lines

The Chargers will travel to State Farm Stadium in Glendale, Arizona, to take on the Cardinals. The matchup is set for 4:05 p.m. ET and can be seen on CBS.

It’s looking all too familiar for Chargers fans. Start the year off hot and then cool down. Los Angeles (5-5) has dropped its last two games against San Francisco (22-16) and Kansas City (30-27).

Patrick Mahomes broke many hearts at SoFi Stadium when he led a 6-play, 75-yard drive resulting in a Travis Kelce touchdown securing the victory for the Chiefs. Justin Herbert had just given his team the lead with 1:46 on the clock but left too much time for the dangerous Mahomes.

Los Angeles is now two spots from a Wildcard spot. Brandon Staley will have to figure out a way to get back on track if he wants to earn him and Herbert their first postseason berth.

Arizona (3-7) comes into the game after being routed by the 49ers (38-10) on Monday Night Football in the Estadio Azteca in Mexico City. Kyler Murray will return from a hamstring injury this week after missing the contest.

Oddsmakers at DraftKings Sportsbook are favoring the Chargers by 2.5 points. On the moneyline, Los Angeles sits at -155 odds and Arizona is +130. The public has placed 53% of their money on the Chargers to cover and 86% of wagers are on the Chargers to win straight up.

Players to watch in the Chargers vs. Cardinals contest


Joshua Palmer: The 2021 3rd-round pick is having a breakout year. The former Tennessee Volunteer has recorded 45 receptions (most among LA wide receivers) for 496 yards and three touchdowns. Last week against Kansas City, Palmer posted eight receptions for 106 yards and two touchdowns. 


DeAndre Hopkins: The Pro Bowl wide receiver has been on fire since returning from his six-game suspension due to the use of PEDs. In four of the five games, Hopkins has eclipsed 91 receiving yards (487 total) and has found the end zone twice.

Chargers vs. Cardinals prediction and odds

Our NFL bet of the week for the Chargers vs. Cardinals

ESTNN is providing bettors with two free selections for this game.

Los Angeles vs. Arizona Spread: Chargers -2.5 @ -120 (DraftKings)

If Staley and the Chargers learned how to close out games and win tight battles, they’d probably be higher in the AFC standings with a playoff seed. Three of their five defeats have come by six points and three points (twice).

Los Angeles is in the top half of the table offensively. The unit ranks 13th in total offense (350.2 YPG) and is scoring 22.7 points per week (14th). 

On defense, the Chargers have been much worse. They are giving up 369 yards per game (25th) and are surrendering 25.8 points per contest (fourth-worst).

In his third year, Herbert continues to post top-10 numbers. Herbert has had the odds stacked against him with receiver Keenan Allen missing most of the season with a hamstring issue and deep threat Mike Williams missing games as well.

Justin Herbert Stats

Passing yards: 2,730 (6th)

Touchdown passes: 16 (T-9th)

Interceptions: 7 (T-19th)

Quarterback rating: 58.7 (12th)

Murray hasn’t made the strides Arizona brass hoped he’d make in his fourth season. The 2019 No. 1 overall pick ranks 23rd in the league for quarterback rating (47) and is 25-29-1 as a starter.

The Oklahoma product has thrown for 2,168 yards, 12 touchdowns and six interceptions. He’s also added 359 yards on the ground along with two scores.

The Cardinals’ offense is 18th in the league in points per game (21.8) and 19th in yards per game (331.9). They are 24th in total defense (360.3 YPG) and rank second-worst for points surrendered (26.9 per contest).

Against the spread, the Chargers have gone 7-3 this season. They are 4-1 ATS in the last five meetings vs. Arizona. The Cardinals are 5-6 ATS and are 0-5 ATS the spread when hosting the Los Angeles.

At ESTNN, we believe the Chargers will come out hungry to climb back to a winning record. Kliff Kingsbury and the Cardinals are a much easier opponent and Herbert will likely win the quarterback battle. DraftKings is offering -120 odds for the Chargers to cover the 2.5-point spread. 

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Chargers vs. Cardinals odds: Justin Herbert over 1.5 touchdown passes @ -179 (Caesars)

Justin Herbert has thrown for at least two touchdowns in 50% of games this season. In those five games, he’s thrown three touchdowns twice.

Last year, Herbert threw two or more touchdowns in 12-of-17 games. This week, he’ll line up against a putrid Arizona secondary that has given up 13 passing touchdowns in the last five weeks.

QB touchdown passes vs. the Cardinals (last five games)

Jimmy Garoppolo (SF): 4 touchdowns

John Wolford (LA): 1 touchdown

Geno Smith (SEA): 2 touchdowns

Kirk Cousins (MIN): 2 touchdowns

Andy Dalton (NO): 4 touchdowns

Our pick is to take the Herbert over 1.5 touchdown passes against the Cardinals’ 23rd-ranked pass defense. The prop is offered on Caesar’s Sportsbook at -179 odds.

If you’re interested in learning about more prop bets for week 12, read our NFL player props page.

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Frequently asked questions regarding Los Angeles vs. Arizona in week 12

Gale Gilbert played in the 1995 Super Bowl but failed to capture the Lombardi Trophy. The organization was defeated 49-26 at the hands of the 49ers. 

If you’re interested in seeing other game lines, read our NFL odds for this week page for more information. 

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