Arizona Cardinals vs. Denver Broncos Odds, Spread, Preview: NFL Week 15 Predictions

By Lawrence Smelser

Arizona Cardinals vs. Denver Broncos Week 15 matchup preview and current betting lines

Arizona will head to the Mile High City to take on the Denver Broncos on Sunday. Kickoff is slated for 4:05 p.m. ET and the matchup can be seen on FOX.

Both of these struggling teams are in a free fall and cannot make the postseason. The Cardinals have lost three-straight games while the Broncos have dropped five consecutive contests.

At 3-10, Denver would usually be in a prime position to earn a top-10 pick in the NFL Draft but doesn’t have one for the next two years since the organization gave them up for Russell Wilson in a trade with Seattle.

Arizona (4-9) will be without starting quarterback Kyler Murray for the remainder of the season after he tore his ACL in last week’s loss to New England.

The Broncos are coming off a narrow 34-28 loss to Kansas City. It was the first time the team managed to score more than 23 points this season.

The Cardinals enter the game after falling 27-13 to New England. Kliff Kingsbury’s men kept the game close in the first half but allowed the Patriots to blow it wide-open in the second.

Oddsmakers at BetMGM Sportsbook give the Broncos a 1.5-point edge over the Cardinals. On the moneyline, Denver is -125 and Arizona is +105. Bettors have put 57% of their bets on the Cardinals to cover and 69% of the money on the Broncos to win outright.

Players to watch in the Cardinals vs. Broncos contest


James Conner: The fifth-year back has missed three games due to injury and hasn’t been the bell cow Kingsbury wanted him to be. Now that he’s healthy, Conner has been consistently earning carries. In his last two games, he’s recorded 40 carries for 205 yards while also recording nine receptions and two total touchdowns.


Jerry Jeudy: The former Alabama star recorded his best day as a pro against the Chiefs last Sunday with three touchdown catches. Jeudy also caught 8-of-9 targets for 73 yards and now has six touchdowns in 2022. He’ll attempt to build off his performance against a weak Cardinals pass defense.

Cardinals vs. Broncos prediction and odds

Our NFL bet of the week for the Cardinals vs. Broncos

ESTNN is providing bettors with two free selections for this game.

Arizona vs. Denver Alternate Spread: Cardinals +1.5 @ -110 (DraftKings)

Despite both of these teams being two of the worst teams in the league, Arizona has kept it competitive against some quality competition such as the Vikings (lost by a touchdown) and the Chargers (lost by one) in recent weeks.

Denver is the worst team in the NFL in terms of current form. Nathaniel Hackett’s squad has lost nine of its previous 10 outings. 

Russell Wilson has been ruled out even though he passed the concussion protocol. Backup quarterback Brett Rypien will start in his place. 

The Boise State product started once in a 16-9 loss to the Jets. Rypien went 24-of-46 for 225 yards, a touchdown and two interceptions.

On the other side, Colt McCoy will lead the Cardinals’ offense. The veteran is 1-2 this season when seeing action and has thrown for 702 yards, one touchdown and two interceptions. The former Longhorn has completed 69.4% of his passes.

The Broncos boast an elite defense that ranks 4th in the NFL in points allowed (18.3) and 7th in total defense (314.3 yards per game). The team’s offense has been awful and ranks dead last in points per game (14.9). The 315.5 yards per game averaged by Denver is 6th-worst in the NFL.

The Cardinals are 6-7 against the spread in 2022 but are 11-4 ATS in their last 15 games on the road. The Broncos are 5-8 ATS and 4-9 ATS in their 13 games played on a Sunday.

At ESTNN we believe Arizona’s experience at quarterback and offensive weapons will prove to be too much for Denver. DraftKings is offering -110 odds for the Cardinals to cover the 1.5-point spread.

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Cardinals vs. Broncos odds: DeAndre Hopkins over 60 rec yards @ -146 (FanDuel)

The Pro Bowl wide receiver missed the first six games of the year due to the use of a banned substance. Since returning, the former Texan has been tearing up secondaries. No matter who is under center, Hopkins continues to produce and garner targets.

Hopkins is averaging 93.3 yards per game, which is 33.3 more yards than the prop provided by FanDuel. In six of the seven contests he’s played in, the 30-year-old has recorded at least 79 yards.

DeAndre Hopkins game log

Week 7 vs. NOLA: 10 rec for 104 yards

Week 8 at MIN: 12 rec for 159 yards

Week 9 vs. SEA: 4 rec for 36 yards

Week 10 at LAR: 10 rec for 98 yards

Week 11 vs. SF: 9 rec for 91 yards

Week 12 vs. LAC: 4 rec for 86 yards

Week 13 vs. NE: 7 rec for 79 yards

Since Marquis Brown is healthy, he’ll force opponents to play single coverage on many snaps against Hopkins. In 2022-2023, the former Clemson Tiger is averaging 10.7 targets per contest.

Our advice is to wager the over that Hopkins will record more than 60 receiving yards on FanDuel Sportsbook at -146 odds. If you’re interested in learning about more prop bets for week 15, read our NFL player props page.

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Frequently asked questions regarding Arizona vs. Denver in week 15

The Broncos received Wilson from Seattle and gave up two first-round picks, two second-round picks, a fifth-round pick, quarterback Drew Lock, defensive lineman Shelby Harris and tight end Noah Fant. Denver also received a fourth-round selection.

If you’re interested in seeing other game lines, read our NFL odds for this week page for more information. 

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